Annual report pursuant to Section 13 and 15(d)

11. INCOME TAXES (Tables)

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11. INCOME TAXES (Tables)
12 Months Ended
Dec. 31, 2018
Income Tax Disclosure [Abstract]  
Schedule of reconciliation of income taxes
    Year Ended December 31,
    2018   2017
Benefit at U.S. federal statutory rate   $ (13,806,124 )   $ (14,758,443 )
State taxes - deferred     (1,443,538 )     (1,581,844 )
Increase in valuation allowance     (1,015,582 )     (751,505 )
Research and development credits     (223,735 )     (272,262 )
Federal tax reform rate change     —         17,263,248  
Decrease in federal net operating loss     12,090,203       —    
Decrease in federal research and development credits     4,294,344       —    
Other     104,432       100,806  
Benefit for income taxes   $ —       $ —    
Schedule of deferred tax asset
    Year Ended December 31,
    2018   2017
Federal and state net operating loss carryforwards   $ 26,080,351     $ 29,137,918  
Federal and state research credits     525,248       4,526,201  
Interest expense limitation carryforwards     1,159,422       —    
Transaction costs     1,147,581       1,269,443  
Deferred revenue     624,610       679,068  
Accrued expenses and other     6,011,057       951,219  
Total gross deferred tax assets     35,548,269       36,563,849  
Less: valuation allowance for deferred tax assets     (35,548,269 )     (36,563,849 )
Net deferred tax assets   $ —       $ —