Annual report pursuant to Section 13 and 15(d)

11. INCOME TAXES (Details)

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11. INCOME TAXES (Details) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Income Tax Disclosure [Abstract]    
Benefit at U.S. Federal statutory rate $ (13,806,124) $ (14,758,443)
State taxes - deferred (1,443,538) (1,581,844)
Increase in valuation allowance (1,015,580) (751,505)
Research and development credits (223,735) (272,262)
Federal tax reform rate change 0 17,263,248
Decrease in federal net operating loss 12,090,203 0
Decrease in federal research and development credits 4,294,344 0
Other 104,430 100,806
Benefit for income taxes $ 0 $ 0